🧱 The First Principles of Inflammatory Bowel Disease

IBD is characterised by both an aberrant immune response and loss of epithelial barrier integrity in the gut, which leads to acute-on-chronic flare ups of immune dysregulation and inflammation.
The inflammatory processes in Ulcerative Colitis (UC) are confined to the mucosa and submucosa, whereas the inflammation in Crohn’s Disease (CD) is transmural, meaning it affects all layers of the gut including the muscularis as well as adventitia/serosa.
UC inflammation begins in the rectum and ascends through the large intestine proximally, whereas CD can affect anywhere along the GI tract, typically the ileocaecal region.

Epidemiology

Inflammatory Bowel Disease (IBD) Explained

🩺 Clinical Features

🔎 Investigations (Acute Severe Ulcerative Colitis Case)

💊 Management

⚠️ Complications

🌐 Resources

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